I have looked thru many threads and have seen some say that if you install the iForged wheels with a 5" lip you can not install a big brake upgrade. Is this true of just iForged or any wheel or is it true at all?

Would like to get a 19/20 set of iForged wheels in Essen or Astra with the 5" lip but also want some huge brake behind them. What is the limiting factor, can you run big brakes behing CCW wheels?